16. Formation and characterization of Ni(II) complex of sodium 1, 4-dihydroxy-9, 10-anthraquinone-2-sulphonate, an analogue of the core unit of anthracycline antibiotics, by different spectroscopic techniques  

Partha Sarathi Guin^a, Saurabh Das^b, P. C. Mandal<sup>a,*

a</sup> Chemical Sciences Division, Saha Institute of Nuclear Physics, 1/AF-Bidhannagar, Kolkata- 700064, India
^b Department of Chemistry, Jadavpur University, Raja S. C. Mullick Road, Kolkata- 700032, India
Corresponding author. Tel.: +91 33 23375345; Fax: +91 33 23374637.
E-mail address: pc.mandal@saha.ac.in (P. C. Mandal)

Abstract: Complex formation between Ni(II) and sodium 1,4-dihydroxy-9,10-anthraquinone-2-sulphonate (sodium quinizarin-2-sulphonate, NaLH₂), an analogue of the core unit of anthracycline drugs was studied in aqueous solution and solid state using different spectroscopic techniques. At neutral and acidic pH, Ni(II) forms a 1:2 metal-ligand complex with sodium quinizarin-2-sulphonate. The effective stability constant of the complex was found to be 2.46 ´ 1013. The complex Na₂[Ni(NaLH)₂Cl₂].2H₂O was synthesized and characterized by different techniques in solid state as well as in solution


Key Words: Ni(II), Sodium quinizarin-2-sulphonate, Stoichiometry, Stability constant.

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